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With insulin: It is necessary to monitor blood sugar levels to avoid the risk of hypoglycemia

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Carcinogenesis: failure of resolution of inflammation

For retatrutide , Phase 2 trial data published in the New England Journal of Medicine (2023) demonstrated highly significant weight loss outcomes in adults with obesity (without type 2 diabetes)

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For neurological applications, the evidence is more preliminary and the extrapolation from rodent to human more uncertain