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Understanding the physiological reasons behind this, from water retention to metabolic adaptation, is essential before drawing any conclusions about whether your calorie deficit is working
If you have or have had depression, suicidal thoughts, or other mental health issues
this is of particular concern in older adults or those taking diuretics or medicines acting on the reninangiotensinaldosterone system (RAAS) Of greater concern for long-term use are potential risks identified with related drug classes : Thyroid C-cell tumours : Studies in rodents have shown C-cell tumours with GLP-1 receptor agonists
They include receiving a product with the wrong potency, contamination, or one made from unapproved ingredients
A 2025 meta-analysis published in Endocrinology, Diabetes & Metabolism, pooling data from four studies with nearly 29,000 patients, confirmed a consistent advantage for tirzepatide, with an average additional weight reduction of 4.84 kg compared to semaglutide
The 4mg dose produced 15.2% reduction
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