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Under US law, compounding pharmacies can make and sell patent-protected drugs that are on the FDA's shortages list in limited amounts, and have been reaping the rewards of supplying versions of Novo Nordisk's obesity drug Wegovy and Ozempic for diabetes, which are both based on the GLP-1 receptor agonist

And this time, the stakes are life and death

Shortening the fatty acid chain length of rat ghrelin was reported to gradually increase the EC 50 (half maximal effective concentration) for receptor activation by 10-fold with hexanoyl (C6:0), 200-fold with butyryl (C4:0), and 500-fold with acetyl (C2:0) (Matsumoto et al., 2001)

GLP-1 DRUGS & AVAILABLE DOSAGE FORMS The first drug in this class for treatment of type 2 diabetes, Exenatide (Byetta ), received approval from the US FDA in 2005