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doi: 10.3389/fimmu.2025.1650194 Received 19 June 2025 Accepted 04 September 2025 Published 23 September 2025 Volume 16 - 2025 Edited by Pedro Gonzalez-Menendez, University of Oviedo, Spain Reviewed by Roberto Luisetto, University of Padua, Italy Fan Shen, University of Alberta, Canada Updates Copyright 2025 Wu, Wang, Yang, Xia, Lou, Fei, Wang and Dai