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However, based on the clinical trial criteria used in studies such as the Phase 2 trial published in the New England Journal of Medicine (2023), researchers have investigated its use in adults with: Obesity , defined as a body mass index (BMI) of 30 kg/m or above Overweight (BMI 27 kg/m or above) with at least one weight-related comorbidity, such as hypertension, dyslipidaemia, or obstructive sleep apnoea Type 2 diabetes , where improved glycaemic control alongside weight reduction is a treatment goal In clinical trials, participants were typically adults without a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2)
It can be due to less appetite and delayed stomach emptying, which might consume less food
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There is no established contraindication, but there is also limited data on interactions
30 An early peak in acute pancreatitis also occurred within the first 60 days of starting therapy in the SCALE trial
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