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however, it leads to dependence when combined with opioids such as hydrocodone and oxycodone

PubMed: 38937282 Wilding JPH, et al

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During puberty, hypothalamic gonadotropin-releasing hormone (GnRH) stimulates the pituitary secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which trigger ovarian estrogen production, marking the onset of estradiol increase and the beginning of ovarian cycles [52]

ClemmensenCChabenneJFinanBSullivanLFischerKKuchlerDet al

This strategy is especially useful for high-risk medications

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