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The initial side effects often become less intense or may disappear altogether

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Glycemic profiling may include fasting/post-prandial glucose, insulin, C-peptide, and HOMA-IR surrogates

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202 g Fmoc-Gly-Wang Resin (100 mmol) with a degree of substitution of 0.496 mmol/g was weighed and swelled for 30 min with DMF, followed by sequentially coupling according to the amino acid sequence of Semaglutide with 2-5 equivalents of amino acid feeds and condensing with DIC+A or B+A+C, until the resin was detected to be transparent with ninhydrin, wherein A was HOBt or HOAt