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Being overweight or obese can lead to a number of health complications and exacerbate the risk of more negative health outcomes when another condition arises
Long-term treatment with low doses of GW-9508-another GPR40 agonist-decreased circulating glucose and insulin levels significantly, which resulted in improvements in glucose intolerance in high fat diet-induced diabetic mice [58]
Therefore, the sponsors concluded that clinically significant DDIs mediated by direct inhibition of CYP enzymes or transporters are unlikely to occur with the administration of GLP-1 RAs and a dual GLP-1/GIP RA
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PMID 25649658
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