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The initial study, by Alberti et al
People whose bodies do not generate enough intrinsic factor can become vitamin B12 deficient
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Temperature shock can cause precipitation, where the peptide crashes out of solution and forms visible particles that indicate permanent damage
This is largely due to the presence of l-glutathione, a compound known to inhibit melanin production which causes darkening of the skin
J Biol Chem 282:2947081, PMID: 17690092 Franco R, Cidlowski JA (2009) Apoptosis and glutathione: beyond an antioxidant
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