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Modulation of transforming growth factor-beta (TGF-beta), integrins, and stem cell pathways have also been observed
MILS and NARP syndrome are associated with seizure rates of 86 and 44%, respectively, with generalized seizures being the most frequent type (110)
& Lambert, W
Metabolic remodeling promotes cardiac hypertrophy by directing glucose to aspartate biosynthesis
Two of these pathways involve the addition of highly water-soluble structures: glucuronate via the glucuronide pathway or sulfate via the sulfation pathway
A decrease in the fatty acid metabolite heptanoic acid was also observed, indicating an increased use of fatty acids as an alternative energy source, via -oxidation to acetyl-CoA and propionyl-CoA 85 .This use of fatty acids is further reinforced by elevated malonate levels in barren urchins, as malonate is converted to malonyl-CoA via the ATP-dependent enzyme acetyl-CoA carboxylase, the primary step in fatty acid synthesis 91
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