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Increasing attention has been directed toward the concept of a therapeutic window of opportunity, which frames early PsA as a transitional phase characterized by musculoskeletal symptoms such as arthralgia, dactylitis, and subclinical enthesitis in patients with PsO, often preceding clinically evident arthritis (72), reported that GLP-1RA treatment in PsO patients receiving systemic therapy did not significantly alter the subsequent risk of developing PsA