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Mutations in genes encoding other components of the PDHc, including the PDHB gene and the DLAT gene, have been shown to be associated with PDH deficiency syndromes
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L-carnitine helps generate energy
Supporting this, a 2026 randomised trial by Lopresti and Smith showed that six weeks of supplementation with 2 g daily of Magtein (magnesium L-threonate) led to significant cognitive improvements (p=0.043) and a 7.5-year reduction in estimated brain cognitive age [5]
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