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B vitamins are essential for converting dietary intake into energy and supporting nervous system health
Recently, hypoxia-induced expression of the SLC1A5 variant was shown to be mediated by HIF-2 and to lead to metabolic reprogramming toward glutamine metabolism in pancreatic cancer cells 16
*Correspondence: Yi Hua, [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
It is naturally produced in our bodies and is found in every cell, particularly in the liver
Interestingly, when FOXO4 expression was silenced in TM3 cells using siRNA prior to H2O2 treatment, cell viability decreased, and apoptosis increased, despite elevated p53 levels
