Blockade of the Chemokine Receptor CXCR2 Ameliorates Adjuvant-Induced Arthritis in Rats
The efficacy and safety of combinations of SGLT2 inhibitors and GLP-1 receptor agonists in the treatment of type 2 diabetes or obese adults: a systematic review and meta-analysis
doi: Aronne LJ, Sattar N, Horn DB, et al
Exenatide Once Weekly Versus Placebo in Parkinsons Disease: A Randomised, Double-Blind, Placebo-Controlled Trial
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GLP-1RA activates the GLP-1 receptor in platelets, through an cyclic adenosine monophosphate/protein kinase (AMP/PKA)-dependent mechanism to prevent systemic inflammation, vascular dysfunction, and end-organ damage, thereby significantly reducing the microvascular thrombosis induced by endotoxin blood disease and mortality (Steven et al., 2016) (Tests on human vascular endothelial cells exposed to LPS have demonstrated that GLP-1 analogs reduce vascular permeability and lower the levels of pro-inflammatory cytokines (Wonhwa et al., 2016)