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Mutations and damage to mitochondrial DNA can affect the function of oxidative phosphorylation complexes, leading to increased ROS generation
Methods: We identified and studied metabolites and soluble biomarkers in plasma from LC individuals mainly exhibiting ME/CFS compared to age-sex-matched recovered individuals (R) without LC, acute COVID-19 patients (A), and to SARS-CoV-2 unexposed healthy individuals (HC)
10.1126/science.1077209 Science 8 BraakH.Del TrediciK.RubU.De VosR
doi: 10.3168/jds.2013-7679 96 OwenJ
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