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Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response

Nearly all G6PD pathogenic variants are single nucleotide missense variants resulting in the substitution of a single amino acid

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Bose P, MD, Masarova L, MD, Pemmaraju N, MD, Bledsoe SD, Daver N, MD, Jabbour EJ, MD, Kadia TM, MD, Estrov ZE, MD, Kornblau SM, MD, Andreeff M , MD, PhD, Cortes JE, MD, Jain N, MD, Borthakur G, MD, Alvarado Y, MD, Huynh-Lu J, Assistant P, Nguyen-Cao MM, Assistant P, Richie MA, Dobbins MH, McCrackin SA, Zhou L, Pierce SA, BSN, BA, Wang X, MS, Pike AM, RN, Garcia-Manero G, MD, Kantarjian H, MD, Verstovsek S, MD, PhD

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Deficiency of glutathione puts the cell at risk for oxidative damage