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Products marketed as "GLP-1 patches" typically contain botanical extracts, amino acids, or vitamins rather than actual GLP-1 receptor agonists
Nevertheless, the target for GIPR antagonists is believed to be a neuronal population in the brain, as a peptideantibody conjugate that blocks GIPR while activating GLP-1R required central GIPR for maximal weight loss in DIO mice, as determined using mice lacking Gipr in cells expressing synapsin 12
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