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The research is strongest in soft-tissue repair and gastrointestinal protection models, with evidence showing benefit in tendon healing, ligament repair, muscle injury, wound healing, angiogenesis, inflammatory modulation, and gut mucosal protection

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NNMT has been explored as a target in obesity, insulin resistance, and age-related metabolic decline, supporting the rationale for translational research into body composition and performance contexts (Kannt & Pfenninger, Frontiers in Physiology )

This was often accompanied by enrichment of pro-inflammatory Proteobacteria and depletion of protective phyla such as Verrucomicrobia, indicating a shift toward inflammation and barrier dysfunction (Stolfi et al., 2022)

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Most creatine is stored in skeletal muscle, with up to five percent found in the brain, liver, kidneys, and pancreas