Cell Genom
[PMID: 3074354] PubMed record related to this compound for laboratory literature review
for instance, drugs designed to modulate brain mitochondria must penetrate the BBB, which can be achieved through nanoparticle conjugation or chemical modification to enhance lipophilicity [19]
Our unpublished calculations, using a structure similar to the models previously employed [2] for studying B12-dependent processes with the CASSCF electronic structure method, which involves 13 electrons and 13 orbitals in their active zone, reveal that the bio-inactive cofactors, aquacobalamin and cyanocobalamin, cannot directly participate in vitamin B12-dependent reactions
A careful skeptic would say: the in-clinic procedure has solid evidence, the at-home extension is biologically plausible and consistent with the procedure, but the dataset is younger than the recommendation implies
References Huang T, Zhang K, Sun L, et al