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For some patients, maintenance involves: A lower dose than used during active weight loss Less frequent dosing Continued appetite support without ongoing weight loss The purpose of maintenance is stability, helping appetite feel manageable while healthy habits are fully established
In the COMBINE 3 trial in individuals with T2D inadequately controlled on daily basal insulin, IcoSema provided non-inferior reduction in HbA 1c from baseline to week 52 and superior body weight change and rate of combined clinically significant or severe hypoglycemia compared with basal-bolus insulin treatment that included once-daily insulin glargine U100 and insulin aspart given two to four times per day with main meals [15]
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That being said only 4.1 % of patients stopped the 4mg dose which is less than the placebo arm
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