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In healthy individuals, the NM content in the SN begins to accumulate at approximately 3 years of age and continues to increase with age, reaching concentrations of 24 mg per gram of wet tissue after the age of 50 ( Physiologically, NM acts as a neuroprotective agent
These processes involve expression of cold-responsive genes, many of which are regulated by GABA
For the duration of the study, animals were singly housed in standard individually ventilated cages (Innovive, San Diego, CA) with nesting material enrichment (ALPHA-Twist
225, 2014 [30] S
Although serum alcohol levels were not significantly reduced, acetaldehyde levels were substantially lower in the GSH group compared to the placebo group
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