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Expression of Ngn3 directs differentiating secretory progenitors toward endocrine fate, while expression of Neurod1 directs differentiating EEC progenitors toward EECs such as L-cells

[1] [2] Marketed under brand names including Ozempic, Wegovy, and Rybelsus, semaglutide works by mimicking the incretin hormone GLP-1, which enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

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