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CSF sampling, including biobank sampling, is performed pre-randomization and at week 78
These appear around the small area of skin where the drug is injected
One SOD3 form (termed the type C subunit) interacts tightly with heparin in the extracellular matrix (ECM), the other (termed the type A subunit) does not interact with the extracellular matrix
doi: 10.1136/ard-2023-224762
& Cao, R
Gene expression studies confirm direct effects on pathways controlling hair growth, and the combination of preclinical efficacy plus clinical success in topical applications supports the rationale for injectable use
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