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While oral glutathione supplements are available, they are often broken down in the digestive system before reaching the bloodstream

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To demonstrate the role of GSH in chemotherapy resistance, we analyzed transcriptomic data from chemotherapy patient samples in the GEO database and collected post-chemotherapy samples from patients who underwent neoadjuvant chemotherapy, assessing the expression levels of GSH and GSH synthesis-related antioxidant enzymes

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The results revealed that the duration of contraceptive use was significantly negatively correlated with vitamin E levels (r = 0.67, p = 0.001) and GPX activity (r = 0.56, p = 0.004), indicating that longer use of oral contraceptives is associated with a greater decrease in these antioxidants