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The aim of this review is to provide an overview of how abnormal lipid metabolism leads to lipotoxicity and the cellular mechanisms of lipotoxicity in the context of NAFLD

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Over time, these can progress to more serious neurological abnormalities

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Although the absolute risk remains relatively low, studies show a modest but consistent increase in gallstones and cholecystitis among treated patients compared to placebo

Complete numerical estimates for Figures 1 5 , including adjusted odds ratios, 95% confidence intervals, and p-values, are provided in Supplementary Table 1