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Mechanisms of Action Oral semaglutide amplifies the effects of the body's natural GLP-1 hormone by: Stimulating insulin release when blood sugar levels rise, aiding in blood sugar control without causing hypoglycemia
Years of post-marketing data, cardiovascular outcome trials showing actual event reduction, kidney benefits, and extensive real-world experience provide a level of certainty that retatrutide simply cannot match yet
Similarly, in the SYNERGY-NASH study (Table 3), improvement of at least one fibrosis stage without worsening of MASH was almost doubled with tirzepatide treatment than with placebo [5]
That delayed stomach emptying is part of how they work