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I know that if Im not also working out and vigilant about all the other things, it doesnt work for me." In a December 2025 interview with PEOPLE, she revealed that she stopped taking GLP-1 injections "cold turkey" on her 70th birthday in an effort to "beat the medication." After gaining 20 pounds, she realized that being on the medication was "going to be a lifetime thing." Winfrey said she was treated differently when she weighed more Winfrey has shared her personal experiences with the social bias that comes with weighing more, saying she was treated poorly when she was over 200 lbs., especially when it came to shopping

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The FDA labeling includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, though the relevance to humans remains uncertain