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quadrupel therapy: amoxicillin 1000 mg 2X daily and clarithromycin 500 mg 2X daily along with proton pump inhibitor 30 mg, also 2X daily and pepto bismal 2X daily

Both relate to NAD metabolism but through different mechanisms

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Because SAM is also required for many other methylation reactions, including gene-expression regulation, high NNMT activity draws heavily on SAM and is associated in studies with reduced NAD, a coenzyme central to cellular energy production