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NH2-triP is then transformed into 6-pyruvoyltetrahydrobiopterin (6-PTP) by 6-pyruvoyl tetrahydrobiopterin synthase (PTPS), and finally, 6-PTP is reduced to BH4 via three successive reactions catalyzed by sepiapterin reductase (SPR)

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70 Further research indicates that aside from inherent antimelanoma activity, NBDHEX also has the ability to enhance the function of temozolomide, with the two able to work synergistically to suppress tumor growth