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This technique helps to confirm ligand interaction by showing the presence of conformational changes when the polyamine ligand is present through the change in RNA cleavage patterns as the concentration of the polyamine ligand is varied
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Pulse rate and laboratory parameters were measured at screening, run-in (laboratory parameters only), randomization, every 4 weeks to week 24, then at weeks 32, 44, 52 and 104
And there are important lingering questions left to resolve
