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SURMOUNT-1 showed 22.5% mean body weight loss at 72 weeks with tirzepatide 15 mg [11]
Physiological replacement of GLP-1 by exogenous administration had little effect, but this may underestimate the role of endogenous GLP-1 for insulin secretion, because intravenous administration bypasses important hepato-portal sensors for GLP-1 [63]
But if our battery isn't balanced, it's possible for the total voltage to be above the cutoff threshold, yet still have a cell below the 3.0V danger zone
The next months decide if its a comeback or just a great post
Pharmacological targeting of the hepcidin/ferroportin axis
Maintenance GI often settles while appetite stays low
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