new england journal of medicine semaglutide NEJM on X: "In an interim analysis a phase 3 trial involving 800 patients with metabolic dysfunction–associated steatohepatitis, once-weekly improved liver histologic results at 72 weeks. Full ESSENCE trial results In the REDEFINE 1 phase

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189,190 In addition, the mitochondrial PGC-1 signaling pathway is also the mechanism of GLP-1 RA to protect neurons from tau hyperphosphorylation, indicating that mitochondrial dysregulation has crosstalk with tau pathology

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