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Placebo capsules comprised microcrystalline cellulose (REDWELLS HEALTH LTD, London, UK) combined with 10% (w/w) gum Arabic (CAS 9000-01-5, Willy Benecke, Hamburg, Germany), matching the gum Arabic content of the pomegranate extract, and 1% (w/w) brown food coloring (rainbow dust edible powder color, Cake Decorating Co., UK) to ensure that the pomegranate and placebo capsules were identical in appearance
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Of note, the dose is based on the basal insulin component in units
In supplement form, you may have heard of it used to treat nausea caused by motion sickness, pregnancy, or chemotherapy
This suggests that Ex-4 mediates its protective effects through a GLP-1-R-SIRT1-p53 signaling axis [41]
5d and Supplementary Fig
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