Volume is the issue as much as content
A review of GLP-1 agonist studies using the standard dose in high intracranial pressure reported: Patients should be counseled about the high likelihood of nausea and GI upset (diarrhea, vomiting, and constipation, delayed gastric emptying) especially in the first 48 weeks of therapy
The team at Elite Primary Care Group manages this through a Start Low, Go Slow philosophy: Gradual Titration: Patients are started on a very low dose to introduce the medication to the body gently
But with age, things start to go downhill, with production declining about 10% per decade after your 20s, which means that by your 50s and 60s, when your body really needs it most, youre running on half a tank, if that
doi: 10.2174/1573399812666151223093841 230 BornerTShaulsonEDTinsleyICSteinLMHornCCHayesMRet al
Importantly, we found that addition of FXR-antagonistic BAs, including TMCA, HDCA or UDCA, could antagonize the effect of CDCA, a potent FXR agonist, on the mRNA expression of Shp and GLP-1 secretion in NCI-H716 cells (Fig