This complex is capable of passing through the inner membrane via the acyl-carnitine/carnitine transporter, following which the fatty acyl group is translocated from L-carnitine to coenzyme A present within the mitochondria by carnitine acyltransferase II enzyme
the published evidence base sits in animal models, cell culture, and small preclinical studies
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These uncertainties do not make the CNS findings irrelevant, but they do mean the area should be described as exploratory and preclinical rather than established