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Our choice of metformin as a proof-of-concept test as a CI inhibitor 79 in these orthotopic models was based on several factors: (1) it could easily be taken forward safely into in vivo studies with known target concentrations

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It is intended solely for laboratory use and in vitro studies , not for human or animal consumption

Tomosugi N, Yamamoto S, Takeuchi M, Yonekura H, Ishigaki Y, Numata N

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