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Yes, they are safe and effective
The triple agonist mechanism offers a coherent, powerful scientific rationale
Nono S, et al
In routine Indian outpatient practice, the phenotype framework above is best used as a starting filter rather than a rigid algorithm: most patients present with overlapping features an obese patient with fatty liver and post-meal spikes, for instance and the choice of agent should weigh cost, injection tolerance, local drug availability, and comorbidity burden alongside the mechanistic fit
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Interest in these medications has recently accelerated, largely for their weight-loss effects, although access to and use of GLP-1 RA medications may be impacted by high cost, limited insurance coverage for patients without T2D and medication shortages
