pharmaceutical market produce revenue erosion curves that are steep and rapid: branded market share typically falls 50% within 12 months of first generic entry and 80-90% within 24 months
In clinical trials, it led to greater weight loss than any currently available medication
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180,181 Therapeutic strategies that target cardiac metabolism, regardless of disease status, have the potential to promote reverse remodeling and improve cardiac function
In addition, the activation of GLP-1R was shown to promote synaptic plasticity and axonal growth (90)