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Bifunctional PEGylated exenatide-amylinomimetic hybrids to treat metabolic disorders: an example of long-acting dual hormonal therapeutics
This article shows that activation of hypothalamic GIPR cells/neurons decreases food intake
it avoids meaningful prolactin and cortisol elevation at doses studied, making it the lower-hormonal-spillover option
One notable difference is that tirzepatide is a dual-agonist (GLP-1 and GIP) while retatrutide is a triple-agonist (GLP-1, GIP, and glucagon)
Hashimotos disease is the most common cause of hypothyroidism in the United States
A.XieZ.LevittP
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