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Sinomenine inhibits macrophage M1 polarization by downregulating 7nAChR via a feedback pathway of 7nAChR/ERK/Egr-1

A: Most people experience little to no discomfort during the injection

Therapeutic support (chronic illness, high toxic load, recovery): up to 2,000mg daily

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This module was implemented exactly as it appears in (Liu et al , 2018), who experimentally measured intracellular currents (see details in Appendix Note S1 part 4)

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