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No PubMed studies were found to validate any of the specific claims made about the peptide's long-term effects or mechanisms of action

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Many of these placebo-controlled studies have demonstrated that folic acid supplementation improved symptoms in severely depressed patients, elderly depressed and demented patients, and those with major acute depression or schizophrenia, particularly in individuals with RBC folate levels below 453 nmol/L (46)

The one exception is the amino acid cysteine