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Notably, at physiological concentrations, TMAO can enhance the integrity of the bloodbrain barrier through the tight junction regulator annexin A1, limit the reactivity of astrocytes and microglia, and protect the cognitive function of mice from inflammatory challenges

Chatauret N, Coudroy R, Delpech PO, Vandebrouck C, Hosni S, Scepi M, et al

Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus

Dong J, Zhou Y, Liao Z, Huang Q, Feng S, Li Y

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This strategy ensures the glutathione wont have any negative interactions with vitamin C, saline, or Lactated Ringers solution (an alternative base to saline that may be used in treatments involving dehydration or surgery)