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Applying the Mediterranean diet may improve the results, but further studies are needed [71]

Injections provide a direct and concentrated method of supplying the body with vitamin B12 and are of particular value to older populations when normal absorption rates decrease, even in the absence of pernicious anemia

Mol Aspects Med 30:1328 Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL (2009b) Glutathione dysregulation and the etiology and progression of human diseases

Similarly, bitopertin, a glycine reuptake inhibitor being developed by Roche, recently failed in phase 3 trials for treatment of persistent negative symptoms

Improving predictability of in vitro models fits also in the scope of the 3Rs (replacement, reduction, refinement) of animal experiments

FoxO1-deficient -cells lose their identity and revert to pancreatic endocrine progenitors characterized by expressing high levels of neurogenin-3 (Neurog3 high ), and no insulin and MafA expression 22