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The concerted efforts of synthetic chemists over the years have led to a common understating that organo-selenium compounds depending on their chemical structure can mimic GPx-like activity [71,72,73]

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Poor nutrition, stress, and toxins can reduce its levels

382 SIRT3 and SIRT5 stabilize and activate the enzymatic activity of SHMT2 by its deacetylase and desuccinylase activity, respectively, thereby promoting the serine catabolism to drive carcinogenesis

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