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Cheng, Chak Kwong, et al
Its about 10 times more muscle-building anabolic than IGF-1 (12)
However, several drugs, including teprotumumab and BIIB-022, which target IGF-1R, have not shown good therapeutic effects in clinical trials, possibly due to the lack of reliable IGF-1R inhibition biomarkers
doi: 10.1016/j.lfs.2017.08.006
Why am I still optimistic
Preclinical data consistently show neuroprotective effects, though the dedicated EVOKE trial of semaglutide for Alzheimer's disease found no significant benefit
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