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If a patient stops taking Suboxone for more than 1-2 days, returns to opioid use, then tries to restart Suboxone, the patient will likely experience sudden and severe opioid withdrawal symptoms that mimic flu-like symptoms (muscle aches, nausea, vomiting, sweating, chills, tremors and diarrhea)

For example, research by Heinrich et al

(PubMed) Watanabe F, Bito T

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If tiredness and weakness start creeping back, its worth booking a b12 injections after fatigue blood test to check your levels again

Evidence for these combinations remains limited to case reports and small case series, but interest is growing