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dose reductions of these medications may be needed when initiating GLP-1 therapy
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To elucidate the involvement of GLP-1 signaling in the ARC neurons in regulating feeding behavior, we used GLP-1R-ires-Cre knock-in mice [35] and Gcg -Cre recombinase transgenic mice [18], which are unique genetic models for specifically investigating the functions of GLP-1R in the brain and the Gcg (proglucagon) GLP-1 releasing neurons located in the hindbrain, respectively
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