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Another limitation of many of the cited studies was that although the majority of the authors gave justification for research (hypothesis specifically was not always outlined), they did not appear to critically evaluate their own methodologies

doi: 10.1016/j.orcp.2026.01.002 74 StanleyTLFourmanLTFeldpauschMNPurdyJZhengIPanCSet al

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Id recommend a full assessment of the methyl cycle as well as the other related pathways

Mitochondrial damage and activation of the sting pathway lead to renal inflammation and fibrosis

other intestinal hormones such as GIP, PYY, Neurotensin, INSL-5 or the GIP co-secreted Xenin (217) might play an important role (Figure 2)