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We have previously reported that GCLM KO mice have lower GSH/GSSG and Cys/CySS redox ratios in plasma, resulting in positive thiol reduction potentials, i.e., more oxidized thiol redox states
As noted above, the mid-region residues (S19 Cagri- P25 Cagri ) form the prototypical bypass motif that was observed for rAmy/San385, constrained by conserved intramolecular hydrogen bonds between the backbone of L16 Cagri /F23 Cagri and S20 Cagri , and the backbone of P25 Cagri and N21 Cagri (Fig
Journal of Clinical Investigation, 136(4)
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