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[4] In the SURMOUNT-1 obesity trial, a 72-week placebo-controlled study in 2,539 adults with obesity (without diabetes), mean weight change was 15.0%, 19.5%, and 20.9% at the 5, 10, and 15 mg doses versus 3.1% for placebo

For example, IL-22, an effector cytokine expressed by Th17 and Th22 cells, triggers epidermal activation and hyperproliferation in psoriasis patients via STAT3 activation 13

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We are now using these mutants and compounds as points of entry to study questions about (1) molecular hierarchies important for the formation and cardiac progenitor cells

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